4PO6

Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005856	cellular_component	cytoskeleton

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 601

Chain	Residue
A	GLU54
A	CYS57
A	PHE71
A	PHE74
A	HOH799
A	HOH801

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 602

Chain	Residue
A	LYS389
A	GLU390
A	ARG410
A	GLU437
A	HOH788
A	PHE377
A	ASP382
A	LEU388

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 603

Chain	Residue
A	ARG269
A	THR272
A	GLU273
A	ARG274

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by TYK2 => ECO:0000305|PubMed:7526154

Chain	Residue	Details
B	TYR481

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER495

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15337770

Chain	Residue	Details
B	LYS501

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