4OGR
crystal structure of P-TEFb complex with AFF4 and Tat
Summary for 4OGR
Entry DOI | 10.2210/pdb4ogr/pdb |
Descriptor | Cyclin-dependent kinase 9, Cyclin-T1, AF4/FMR2 family member 4, ... (7 entities in total) |
Functional Keywords | p-tefb, cyclin-dependent kinase 9, cyclin fold, intrinsically unstructured aff4, transcriptional regulation at hiv promoter, binds tar, n-terminal acetylation of tat, transferase-viral protein complex, transferase/viral protein |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P50750 O60563 Q9UHB7 Host nucleus, host nucleolus : P69698 |
Total number of polymer chains | 12 |
Total formula weight | 254451.64 |
Authors | Schulze-Gahmen, U.,Alber, T. (deposition date: 2014-01-16, release date: 2014-05-07, Last modification date: 2023-09-20) |
Primary citation | Schulze-Gahmen, U.,Lu, H.,Zhou, Q.,Alber, T. AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter. Elife, 3:e02375-e02375, 2014 Cited by PubMed: 24843025DOI: 10.7554/eLife.02375 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report