4OGR

crystal structure of P-TEFb complex with AFF4 and Tat

4OGR の概要

• エントリーDOI: 10.2210/pdb4ogr/pdb
• 分子名称: Cyclin-dependent kinase 9, Cyclin-T1, AF4/FMR2 family member 4, ... (7 entities in total)
• 機能のキーワード: p-tefb, cyclin-dependent kinase 9, cyclin fold, intrinsically unstructured aff4, transcriptional regulation at hiv promoter, binds tar, n-terminal acetylation of tat, transferase-viral protein complex, transferase/viral protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P50750 O60563 Q9UHB7; Host nucleus, host nucleolus : P69698
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 254451.64

構造登録者

Schulze-Gahmen, U.,Alber, T. (登録日: 2014-01-16, 公開日: 2014-05-07, 最終更新日: 2023-09-20)

• 主引用文献: Schulze-Gahmen, U.,Lu, H.,Zhou, Q.,Alber, T.; AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter.; Elife, 3:e02375-e02375, 2014; PubMed: 24843025; DOI: 10.7554/eLife.02375

実験手法

X-RAY DIFFRACTION (3 Å)