4OGB
Crystal structure of the catalytic domain of PDE4D2 with compound 2
Summary for 4OGB
Entry DOI | 10.2210/pdb4ogb/pdb |
Related | 1PTW 3SL3 3SL4 3SL5 3SL6 3SL8 |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, (2R)-8-(3,4-dimethoxyphenyl)-6-methyl-2-(tetrahydro-2H-pyran-4-yl)-2H-chromen-4-ol, 1,2-ETHANEDIOL, ... (8 entities in total) |
Functional Keywords | catalytic mechanism, camp hydrolysis, hydrolase-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Apical cell membrane : Q08499 |
Total number of polymer chains | 4 |
Total formula weight | 171266.38 |
Authors | Feil, S.C.,Parker, M.W. (deposition date: 2014-01-15, release date: 2015-01-21, Last modification date: 2024-02-28) |
Primary citation | Howard, B.L.,Nankervis, J.L.,Feil, S.C.,Manallack, D.T.,Holien, J.K.,Zhen, Z.,Jennings, I.G.,Abbott, B.M.,Parker, M.W.,Thompson, P.E. The PDE inhibition profile of LY294002 and tetrahydropyranyl analogues reveals a chromone motif for the development of PDE inhibitors To be Published, |
Experimental method | X-RAY DIFFRACTION (2.032 Å) |
Structure validation
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