3SL5

Crystal structure of the catalytic domain of PDE4D2 complexed with compound 10d

Summary for 3SL5

Entry DOI	10.2210/pdb3sl5/pdb
Related	1PTW 3SL3 3SL4 3SL6 3SL8
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, diethyl 2-[(thiophen-2-ylacetyl)amino]-4,7-dihydrothieno[2,3-c]pyridine-3,6(5H)-dicarboxylate, ... (7 entities in total)
Functional Keywords	catalytic mechanism, camp hydrolysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Apical cell membrane : Q08499
Total number of polymer chains	4
Total formula weight	168467.25
Authors	Feil, S.F. (deposition date: 2011-06-24, release date: 2011-10-26, Last modification date: 2024-02-28)
Primary citation	Nankervis, J.L.,Feil, S.C.,Hancock, N.C.,Zheng, Z.,Ng, H.L.,Morton, C.J.,Holien, J.K.,Ho, P.W.,Frazzetto, M.M.,Jennings, I.G.,Manallack, D.T.,Martin, T.J.,Thompson, P.E.,Parker, M.W. Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2. Bioorg.Med.Chem.Lett., 21:7089-7093, 2011 Cited by PubMed: 22030030 DOI: 10.1016/j.bmcl.2011.09.109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation