3SL5
Crystal structure of the catalytic domain of PDE4D2 complexed with compound 10d
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 359 | 41220.6 | 4 | UniProt (Q08499) Pfam (PF00233) | Homo sapiens (human) | DPDE3, PDE43 |
| 2 | AA, BA, E, F, K... (D, A, B, C) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | CA, G, M, S (D, A, B, C) | diethyl 2-[(thiophen-2-ylacetyl)amino]-4,7-dihydrothieno[2,3-c]pyridine-3,6(5H)-dicarboxylate | non-polymer | 422.5 | 4 | Chemie (J25) | |||
| 4 | DA, EA, FA, GA, H... (D, A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 17 | Chemie (EDO) | |||
| 5 | I (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | P (C) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 7 | JA, KA, LA, MA (A, B, C, D) | water | water | 18.0 | 414 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 164882.3 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 3584.9 | |
| All* | Total formula weight | 168467.3 |
