4OGA
Insulin in complex with Site 1 of the human insulin receptor
Summary for 4OGA
Entry DOI | 10.2210/pdb4oga/pdb |
Related | 3W11 3W12 3W13 |
Descriptor | Insulin A chain, Insulin B chain, monoclonal antibody fab 83-7 fragment - heavy chain, ... (9 entities in total) |
Functional Keywords | cell surface receptor/immune system, insulin receptor, ct peptide, insulin, hormone receptor-hormone-immune system complex, hormone receptor/hormone/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 71687.23 |
Authors | Lawrence, M.C.,Menting, J.G. (deposition date: 2014-01-15, release date: 2014-08-27, Last modification date: 2023-09-20) |
Primary citation | Menting, J.G.,Yang, Y.,Chan, S.J.,Phillips, N.B.,Smith, B.J.,Whittaker, J.,Wickramasinghe, N.P.,Whittaker, L.J.,Pandyarajan, V.,Wan, Z.L.,Yadav, S.P.,Carroll, J.M.,Strokes, N.,Roberts, C.T.,Ismail-Beigi, F.,Milewski, W.,Steiner, D.F.,Chauhan, V.S.,Ward, C.W.,Weiss, M.A.,Lawrence, M.C. Protective hinge in insulin opens to enable its receptor engagement. Proc.Natl.Acad.Sci.USA, 111:E3395-E3404, 2014 Cited by PubMed: 25092300DOI: 10.1073/pnas.1412897111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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