4OG6

Human menin with bound inhibitor MIV-4

Summary for 4OG6

Entry DOI	10.2210/pdb4og6/pdb
Related	4OG3 4OG4 4OG5 4OG7 4OG8
Descriptor	Menin, SULFATE ION, 4-(3-{4-[(R)-cyclopentyl(3-fluorophenyl)hydroxymethyl]piperidin-1-yl}propoxy)benzonitrile, ... (7 entities in total)
Functional Keywords	protein binding/inhibitor, protein binding-inhibitor complex
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O00255
Total number of polymer chains	1
Total formula weight	55957.99
Authors	He, S.,Senter, T.J.,Pollock, J.W.,Han, C.,Upadhyay, S.K.,Purohit, T.,Gogliotti, R.D.,Lindsley, C.W.,Cierpicki, T.,Stauffer, S.R.,Grembecka, J. (deposition date: 2014-01-15, release date: 2014-03-05, Last modification date: 2023-09-20)
Primary citation	He, S.,Senter, T.J.,Pollock, J.,Han, C.,Upadhyay, S.K.,Purohit, T.,Gogliotti, R.D.,Lindsley, C.W.,Cierpicki, T.,Stauffer, S.R.,Grembecka, J. High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction. J.Med.Chem., 57:1543-1556, 2014 Cited by PubMed: 24472025 DOI: 10.1021/jm401868d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.49 Å)

Structure validation