4OG6

Human menin with bound inhibitor MIV-4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Menin	polymer	489	54600.2	1	UniProt (O00255) Pfam (PF05053)	Homo sapiens (human)
2	B (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	C (A)	4-(3-{4-[(R)-cyclopentyl(3-fluorophenyl)hydroxymethyl]piperidin-1-yl}propoxy)benzonitrile	non-polymer		436.6	1	Chemie (2S9)
4	D (A)	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
5	E, F, K (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	3	Chemie (PEG)
6	G, H, I, J (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	4	Chemie (DMS)
7	L (A)	water	water		18.0	463	Chemie (HOH)

Sequence modifications

A: 1 - 593 (UniProt: O00255)

PDB	External Database	Details
Gly -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
-	Ile 54	deletion
-	Pro 55	deletion
-	Thr 56	deletion
-	Asn 57	deletion
-	Val 58	deletion
-	Pro 59	deletion
-	Glu 60	deletion
-	Leu 61	deletion
-	Thr 62	deletion
-	Phe 63	deletion
-	Gln 64	deletion
-	Pro 65	deletion
-	Ser 66	deletion
-	Pro 67	deletion
-	Ala 68	deletion
-	Pro 69	deletion
-	Asp 70	deletion
-	Pro 71	deletion
-	Pro 72	deletion
-	Gly 73	deletion
-	Glu 387	deletion
-	Glu 388	deletion
-	Arg 389	deletion
-	Pro 390	deletion
-	Gly 391	deletion
-	Glu 392	deletion
-	Gln 393	deletion
-	Ser 394	deletion
-	Gln 395	deletion
-	Gly 396	deletion
-	Thr 397	deletion
-	Gln 398	deletion
-	Arg 460	deletion
-	Glu 461	deletion
-	Ala 462	deletion
-	Glu 463	deletion
-	Ala 464	deletion
-	Ala 465	deletion
-	Glu 466	deletion
-	Ala 467	deletion
-	Glu 468	deletion
-	Glu 469	deletion
-	Pro 470	deletion
-	Trp 471	deletion
-	Gly 472	deletion
-	Glu 473	deletion
-	Glu 474	deletion
-	Ala 475	deletion
-	Arg 476	deletion
-	Glu 477	deletion
-	Gly 478	deletion
-	Arg 479	deletion
-	Arg 480	deletion
-	Arg 481	deletion
-	Gly 482	deletion
-	Pro 483	deletion
-	Arg 484	deletion
-	Arg 485	deletion
-	Glu 486	deletion
-	Ser 487	deletion
-	Lys 488	deletion
-	Pro 489	deletion
-	Glu 490	deletion
-	Glu 491	deletion
-	Pro 492	deletion
-	Pro 493	deletion
-	Pro 494	deletion
-	Pro 495	deletion
-	Lys 496	deletion
-	Lys 497	deletion
-	Pro 498	deletion
-	Ala 499	deletion
-	Leu 500	deletion
-	Asp 501	deletion
-	Lys 502	deletion
-	Gly 503	deletion
-	Leu 504	deletion
-	Gly 505	deletion
-	Thr 506	deletion
-	Gly 507	deletion
-	Gln 508	deletion
-	Gly 509	deletion
-	Ala 510	deletion
-	Val 511	deletion
-	Ser 512	deletion
-	Gly 513	deletion
-	Pro 514	deletion
-	Pro 515	deletion
-	Arg 516	deletion
-	Lys 517	deletion
-	Pro 518	deletion
-	Pro 519	deletion
-	Gly 520	deletion
-	Thr 521	deletion
-	Val 522	deletion
-	Ala 523	deletion
-	Gly 524	deletion
-	Thr 525	deletion
-	Ala 526	deletion
-	Arg 527	deletion
-	Gly 528	deletion
-	Pro 529	deletion
-	Glu 530	deletion
-	Gly 531	deletion
-	Gly 532	deletion
-	Ser 533	deletion
-	Thr 534	deletion
-	Ala 535	deletion
-	Gln 536	deletion

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	54600.2
Non-Polymers*	Number of molecules	10
	Total formula weight	1357.7
All*	Total formula weight	55958.0

*Water molecules are not included.