4OEP

Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tail

Summary for 4OEP

• Entry DOI: 10.2210/pdb4oep/pdb
• Related: 4OEO 4OEQ
• Descriptor: Tight junction protein ZO-1, DODECAETHYLENE GLYCOL, ACETATE ION, ... (4 entities in total)
• Functional Keywords: maguk, pdz1, scaffolding, cell adhesion, claudin, tight junction assembly
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side: Q07157
• Total number of polymer chains: 2
• Total formula weight: 23614.49

Authors

Nomme, J.,Lavie, A. (deposition date: 2014-01-13, release date: 2015-01-14, Last modification date: 2024-02-28)

• Primary citation: Nomme, J.,Antanasijevic, A.,Caffrey, M.,Van Itallie, C.M.,Anderson, J.M.,Fanning, A.S.,Lavie, A.; Structural Basis of a Key Factor Regulating the Affinity between the Zonula Occludens First PDZ Domain and Claudins.; J.Biol.Chem., 290:16595-16606, 2015; PubMed: 26023235; DOI: 10.1074/jbc.M115.646695

Experimental method

X-RAY DIFFRACTION (2.35 Å)