4OEP

Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tail

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tight junction protein ZO-1	polymer	107	11474.9	2	UniProt (Q07157) Pfam (PF00595) In PDB	Homo sapiens (human)	Tight junction protein 1, Zona occludens protein 1, Zonula occludens protein 1
2	A	DODECAETHYLENE GLYCOL	non-polymer		546.6	1	Chemie (12P)
3	A	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
4		water	water		18.0	43	Chemie (HOH)

Sequence modifications

A, B: 18 - 110 (UniProt: Q07157)

PDB	External Database	Details
Gly 14	-	expression tag
Ser 15	-	expression tag
His 16	-	expression tag
Met 17	-	expression tag
Gly 111	-	expression tag
Gly 112	-	expression tag
Gly 113	-	expression tag
Ser 114	-	expression tag
Ser 115	-	expression tag
Gly 116	-	expression tag
Lys 117	-	expression tag
Asp 118	-	expression tag
Tyr 119	-	expression tag
Val 120	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	22949.8
Non-Polymers*	Number of molecules	3
	Total formula weight	664.7
All*	Total formula weight	23614.5

*Water molecules are not included.