4OCT
Crystal structure of human ALKBH5 crystallized in the presence of Mn^{2+} and 2-oxoglutarate
Summary for 4OCT
Entry DOI | 10.2210/pdb4oct/pdb |
Descriptor | RNA demethylase ALKBH5, MANGANESE (II) ION, 2-OXOGLUTARIC ACID, ... (5 entities in total) |
Functional Keywords | structural genomics, structural genomics consortium, sgc, rna demethylase, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus speckle : Q6P6C2 |
Total number of polymer chains | 2 |
Total formula weight | 51080.09 |
Authors | Tempel, W.,Chao, X.,Liu, K.,Dong, A.,Cerovina, T.,He, H.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2014-01-09, release date: 2014-04-16, Last modification date: 2023-09-20) |
Primary citation | Xu, C.,Liu, K.,Tempel, W.,Demetriades, M.,Aik, W.,Schofield, C.J.,Min, J. Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. J.Biol.Chem., 289:17299-17311, 2014 Cited by PubMed: 24778178DOI: 10.1074/jbc.M114.550350 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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