4O8F
Crystal Structure of the complex between PPARgamma mutant R357A and rosiglitazone
Summary for 4O8F
Entry DOI | 10.2210/pdb4o8f/pdb |
Related | 2PRG 3B3K 4L96 4L98 |
Descriptor | Peroxisome proliferator-activated receptor gamma, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) (3 entities in total) |
Functional Keywords | bundle of alpha-helices, small four-stranded beta-sheet, transcription factor, rxralpha, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 65930.27 |
Authors | Pochetti, G.,Montanari, R.,Capelli, D.,Chiaraluce, R.,Consalvi, V.,Lori, C.,Loiodice, F.,Laghezza, A.,Pasquo, A.,Cervoni, L.,Aschi, M. (deposition date: 2013-12-27, release date: 2014-07-23, Last modification date: 2023-09-20) |
Primary citation | Lori, C.,Pasquo, A.,Montanari, R.,Capelli, D.,Consalvi, V.,Chiaraluce, R.,Cervoni, L.,Loiodice, F.,Laghezza, A.,Aschi, M.,Giorgi, A.,Pochetti, G. Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy. Acta Crystallogr.,Sect.D, 70:1965-1976, 2014 Cited by PubMed: 25004973DOI: 10.1107/S1399004714009638 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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