4O3U
Zymogen HGF-beta/MET with Zymogen Activator Peptide ZAP2.3
Summary for 4O3U
Entry DOI | 10.2210/pdb4o3u/pdb |
Descriptor | Hepatocyte growth factor, Hepatocyte growth factor receptor, ZAP 2.3 (3 entities in total) |
Functional Keywords | trypsin homoloy, receptor activation, transferase-growth factor complex, transferase/growth factor |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P14210 |
Total number of polymer chains | 3 |
Total formula weight | 91301.14 |
Authors | Eigenbrot, C.,Landgraf, K.E.,Steffek, M. (deposition date: 2013-12-18, release date: 2014-06-04, Last modification date: 2023-09-20) |
Primary citation | Landgraf, K.E.,Steffek, M.,Quan, C.,Tom, J.,Yu, C.,Santell, L.,Maun, H.R.,Eigenbrot, C.,Lazarus, R.A. An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides. Nat.Chem.Biol., 10:567-573, 2014 Cited by PubMed: 24859116DOI: 10.1038/nchembio.1533 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.04 Å) |
Structure validation
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