4O3U

Zymogen HGF-beta/MET with Zymogen Activator Peptide ZAP2.3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hepatocyte growth factor	polymer	240	26800.9	1	UniProt (P14210) Pfam (PF00089) In PDB	Homo sapiens (human)	Hepatopoietin-A, Scatter factor, SF, Hepatocyte growth factor alpha chain, Hepatocyte growth factor beta chain
2	B	Hepatocyte growth factor receptor	polymer	551	62714.1	1	UniProt (P08581) Pfam (PF01403) Pfam (PF01437) In PDB	Homo sapiens (human)	HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
3	P	ZAP 2.3	polymer	15	1786.1	1		synthetic

Sequence modifications

A: 495 - 728 (UniProt: P14210)

PDB	External Database	Details
Gly 495	Val 495	engineered mutation
Ser 604	Cys 604	engineered mutation
His 729	-	expression tag
His 730	-	expression tag
His 731	-	expression tag
His 732	-	expression tag
His 733	-	expression tag
His 734	-	expression tag

B: 25 - 567 (UniProt: P08581)

PDB	External Database	Details
His 568	-	expression tag
His 569	-	expression tag
His 570	-	expression tag
His 571	-	expression tag
His 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	91301.1
All*	Total formula weight	91301.1

*Water molecules are not included.