4NXZ

DNA polymerase beta with O6mG in the template base opposite to incoming non-hydrolyzable TTP with manganese in the active site

Summary for 4NXZ

• Entry DOI: 10.2210/pdb4nxz/pdb
• Related: 1BPX 3ISB 4NY8
• Descriptor: 5'-D(*CP*CP*GP*AP*CP*(6OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... (8 entities in total)
• Functional Keywords: dna binding, dna polymerase fold, nucleotidyl transfer, nucleolus, transferase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 47298.69

Authors

Koag, M.-C.,Min, K.,Monzingo, A.F.,Lee, S. (deposition date: 2013-12-09, release date: 2014-04-16, Last modification date: 2024-02-28)

• Primary citation: Koag, M.C.,Lee, S.; Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta.; J.Am.Chem.Soc., 136:5709-5721, 2014; PubMed: 24694247; DOI: 10.1021/ja500172d

Experimental method

X-RAY DIFFRACTION (2.557 Å)