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4NY8

DNA polymerase beta with O6mG in the template base opposite to incoming non-hydrolyzable CTP with manganese in the active site

Summary for 4NY8
Entry DOI10.2210/pdb4ny8/pdb
Related4NXZ
DescriptorDNA polymerase beta, 5'-D(*CP*CP*GP*AP*CP*(6OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', ... (8 entities in total)
Functional Keywordsdna binding, dna polymerase fold, nucleotidyl transfer, nucleolus, transferase, lyase-dna complex, lyase/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P06746
Total number of polymer chains4
Total formula weight47283.67
Authors
Koag, M.-C.,Min, K.,Monzingo, A.F.,Lee, S. (deposition date: 2013-12-10, release date: 2014-04-16, Last modification date: 2024-02-28)
Primary citationKoag, M.C.,Lee, S.
Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta.
J.Am.Chem.Soc., 136:5709-5721, 2014
Cited by
PubMed: 24694247
DOI: 10.1021/ja500172d
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.246 Å)
Structure validation

217705

PDB entries from 2024-03-27

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