4NXR
Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM) in Complex With Neurexin-1 Peptide
Summary for 4NXR
Entry DOI | 10.2210/pdb4nxr/pdb |
Related | 3KZD 3KZE 4GVC 4GVD 4NXP 4NXQ |
Descriptor | T-lymphoma invasion and metastasis-inducing protein 1, Neurexin-2-beta Peptide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (5 entities in total) |
Functional Keywords | beta barrel fold protein, pdz domain, peptide binding, specificity mutant, scaffold signaling protein for cell adhesion and cell junction, signaling domain, signaling protein-peptide complex, signaling protein/peptide |
Biological source | Homo sapiens (human) More |
Cellular location | Cell junction: Q13009 Membrane ; Single-pass type I membrane protein : P58401 |
Total number of polymer chains | 2 |
Total formula weight | 11742.17 |
Authors | Liu, X.,Speckhard, D.C.,Shepherd, T.R.,Hengel, S.R.,Fuentes, E.J. (deposition date: 2013-12-09, release date: 2015-05-13, Last modification date: 2023-09-20) |
Primary citation | Liu, X.,Speckhard, D.C.,Shepherd, T.R.,Sun, Y.J.,Hengel, S.R.,Yu, L.,Fowler, C.A.,Gakhar, L.,Fuentes, E.J. Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions. Structure, 24:2053-2066, 2016 Cited by PubMed: 27998539DOI: 10.1016/j.str.2016.08.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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