4NXQ

Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM) in Complex With Caspr4 Peptide

Summary for 4NXQ

Entry DOI	10.2210/pdb4nxq/pdb
Related	3KZD 3KZE 4GVC 4GVD 4NXP 4NXR
Descriptor	T-lymphoma invasion and metastasis-inducing protein 1, Contactin-associated protein-like 4 peptide (3 entities in total)
Functional Keywords	beta barrel fold protein, pdz domain; peptide binding, specificity mutant, scaffold signaling protein for cell adhesion and cell junction, signaling domain, protein-peptide complex, signaling protein-peptide complex, signaling protein/peptide
Biological source	Homo sapiens (human) More
Cellular location	Cell junction: Q13009 Cell junction, synapse, presynaptic cell membrane ; Single-pass type I membrane protein : Q9C0A0
Total number of polymer chains	6
Total formula weight	33892.73
Authors	Liu, X.,Speckhard, D.C.,Shepherd, T.R.,Hengel, S.R.,Fuentes, E.J. (deposition date: 2013-12-09, release date: 2015-05-13, Last modification date: 2023-09-20)
Primary citation	Liu, X.,Speckhard, D.C.,Shepherd, T.R.,Sun, Y.J.,Hengel, S.R.,Yu, L.,Fowler, C.A.,Gakhar, L.,Fuentes, E.J. Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions. Structure, 24:2053-2066, 2016 Cited by PubMed: 27998539 DOI: 10.1016/j.str.2016.08.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation