4NXR

Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM) in Complex With Neurexin-1 Peptide

Summary for 4NXR

• Entry DOI: 10.2210/pdb4nxr/pdb
• Related: 3KZD 3KZE 4GVC 4GVD 4NXP 4NXQ
• Descriptor: T-lymphoma invasion and metastasis-inducing protein 1, Neurexin-2-beta Peptide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (5 entities in total)
• Functional Keywords: beta barrel fold protein, pdz domain, peptide binding, specificity mutant, scaffold signaling protein for cell adhesion and cell junction, signaling domain, signaling protein-peptide complex, signaling protein/peptide
• Biological source: Homo sapiens (human); More
• Cellular location: Cell junction: Q13009; Membrane ; Single-pass type I membrane protein : P58401
• Total number of polymer chains: 2
• Total formula weight: 11742.17

Authors

Liu, X.,Speckhard, D.C.,Shepherd, T.R.,Hengel, S.R.,Fuentes, E.J. (deposition date: 2013-12-09, release date: 2015-05-13, Last modification date: 2023-09-20)

• Primary citation: Liu, X.,Speckhard, D.C.,Shepherd, T.R.,Sun, Y.J.,Hengel, S.R.,Yu, L.,Fowler, C.A.,Gakhar, L.,Fuentes, E.J.; Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.; Structure, 24:2053-2066, 2016; PubMed: 27998539; DOI: 10.1016/j.str.2016.08.019

Experimental method

X-RAY DIFFRACTION (1.9 Å)