4NXQ

Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM) in Complex With Caspr4 Peptide

4NXQ の概要

• エントリーDOI: 10.2210/pdb4nxq/pdb
• 関連するPDBエントリー: 3KZD 3KZE 4GVC 4GVD 4NXP 4NXR
• 分子名称: T-lymphoma invasion and metastasis-inducing protein 1, Contactin-associated protein-like 4 peptide (3 entities in total)
• 機能のキーワード: beta barrel fold protein, pdz domain; peptide binding, specificity mutant, scaffold signaling protein for cell adhesion and cell junction, signaling domain, protein-peptide complex, signaling protein-peptide complex, signaling protein/peptide
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell junction: Q13009; Cell junction, synapse, presynaptic cell membrane ; Single-pass type I membrane protein : Q9C0A0
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 33892.73

構造登録者

Liu, X.,Speckhard, D.C.,Shepherd, T.R.,Hengel, S.R.,Fuentes, E.J. (登録日: 2013-12-09, 公開日: 2015-05-13, 最終更新日: 2023-09-20)

• 主引用文献: Liu, X.,Speckhard, D.C.,Shepherd, T.R.,Sun, Y.J.,Hengel, S.R.,Yu, L.,Fowler, C.A.,Gakhar, L.,Fuentes, E.J.; Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.; Structure, 24:2053-2066, 2016; PubMed: 27998539; DOI: 10.1016/j.str.2016.08.019

実験手法

X-RAY DIFFRACTION (2.1 Å)