4NWT
Crystal structure of the anti-human NGF Fab APE1531
Summary for 4NWT
Entry DOI | 10.2210/pdb4nwt/pdb |
Descriptor | APE1531 Ab Fab light chain, APE1531 Ab Fab heavy chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (6 entities in total) |
Functional Keywords | beta sandwich, human beta nerve growth factor, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted : P01857 |
Total number of polymer chains | 2 |
Total formula weight | 50070.54 |
Authors | Verdino, P.,Stanfield, R.L.,Wilson, I.A. (deposition date: 2013-12-06, release date: 2014-10-22, Last modification date: 2023-09-20) |
Primary citation | Bowers, P.M.,Verdino, P.,Wang, Z.,da Silva Correia, J.,Chhoa, M.,Macondray, G.,Do, M.,Neben, T.Y.,Horlick, R.A.,Stanfield, R.L.,Wilson, I.A.,King, D.J. Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies. J.Biol.Chem., 289:33557-33567, 2014 Cited by PubMed: 25320089DOI: 10.1074/jbc.M114.607176 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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