4NWT

Crystal structure of the anti-human NGF Fab APE1531

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MES L 301

Chain	Residue
H	GLN61
H	LYS62
H	GLN64
H	ARG66
H	SER128
H	LYS129
L	CYS214
L	MES302

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MES L 302

Chain	Residue
H	LYS129
L	GLU81
L	THR206
L	LYS207
L	SER208
L	MES301
L	HOH438
H	GLN61

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT L 303

Chain	Residue
L	GLN37
L	LYS39
L	LYS45
L	GLU81
L	ASP82

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT L 304

Chain	Residue
H	SER134
L	SER114
L	VAL115
L	LYS207
L	HOH448

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site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT H 301

Chain	Residue
H	ASN216
H	ASP220
H	HOH474

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site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ACT H 302

Chain	Residue
H	PHE174
H	PRO175
H	VAL177
H	SER186
H	LEU187
H	SER188
H	HOH445
H	HOH536
L	SER162
L	SER176

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site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PGE H 303

Chain	Residue
H	ASN58
H	TYR100
H	ARG100
H	TYR100
L	TYR91
L	ASN93
L	TYR94
L	HOH427

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR192-HIS198
H	TYR206-HIS212

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