4NQL

The crystal structure of the DUB domain of AMSH orthologue, Sst2 from S. pombe, in complex with lysine 63-linked diubiquitin

4NQL の概要

• エントリーDOI: 10.2210/pdb4nql/pdb
• 関連するPDBエントリー: 2ZNV 3RZV 4MSM 4MSQ
• 分子名称: AMSH-like protease sst2, Ubiquitin, ZINC ION, ... (6 entities in total)
• 機能のキーワード: jamm domain, zinc metalloprotease, protein complex, amsh, heix-beta-helix sandwich, hydrolase, metal binding, k63-linked diubiquitin, helix-beta-helix sandwich, deubiquitinase, ubiquitin, hse1, cytosol, endosome, hydrolase-protein binding complex, hydrolase/protein binding
• 由来する生物種: Schizosaccharomyces pombe (Fission yeast); 詳細
• 細胞内の位置: Cytoplasm: Q9P371; Cytoplasm (By similarity): P0CG50 P0CG50
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 42457.62

構造登録者

Ronau, J.A.,Shrestha, R.K.,Das, C. (登録日: 2013-11-25, 公開日: 2014-10-08, 最終更新日: 2024-01-10)

• 主引用文献: Shrestha, R.K.,Ronau, J.A.,Davies, C.W.,Guenette, R.G.,Strieter, E.R.,Paul, L.N.,Das, C.; Insights into the mechanism of deubiquitination by JAMM deubiquitinases from cocrystal structures of the enzyme with the substrate and product.; Biochemistry, 53:3199-3217, 2014; PubMed: 24787148; DOI: 10.1021/bi5003162

実験手法

X-RAY DIFFRACTION (2.3 Å)