4NO9

yCP in complex with Z-Leu-Leu-Leu-epoxyketone

Summary for 4NO9

Entry DOI	10.2210/pdb4no9/pdb
Related	1RYP 4NNN 4NNW 4NO1 4NO6 4NO8
Related PRD ID	PRD_001200 PRD_001201
Descriptor	Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total)
Functional Keywords	proteasome, peptide electrophile, binding analysis, irreversible inhibitor, epoxyketone, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Saccharomyces cerevisiae (Baker's yeast) More
Cellular location	Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains	28
Total formula weight	733386.06
Authors	Stein, M.L.,Cui, H.,Beck, P.,Dubiella, C.,Voss, C.,Krueger, A.,Schmidt, B.,Groll, M. (deposition date: 2013-11-19, release date: 2014-02-12, Last modification date: 2023-09-20)
Primary citation	Stein, M.L.,Cui, H.,Beck, P.,Dubiella, C.,Voss, C.,Kruger, A.,Schmidt, B.,Groll, M. Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif. Angew.Chem.Int.Ed.Engl., 53:1679-1683, 2014 Cited by PubMed: 24403024 DOI: 10.1002/anie.201308984 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation