4NKC
Human Aldose Reductase complexed with Schl7764 at 1.12 A
Summary for 4NKC
Entry DOI | 10.2210/pdb4nkc/pdb |
Related | 2IKG 2IKH 3DN5 |
Descriptor | Aldose reductase, (2Z)-3-(3'-nitrobiphenyl-3-yl)prop-2-enoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | tim barrel, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 36779.80 |
Authors | Rechlin, C.,Heine, A.,Klebe, G. (deposition date: 2013-11-12, release date: 2015-03-04, Last modification date: 2023-09-20) |
Primary citation | Rechlin, C.,Heine, A.,Ortmann, R.,Schlitzer, M.,Klebe, G. Keys to open the specificity pocket: Biaryl Inhibitors of the human aldose reductase To be Published, |
Experimental method | X-RAY DIFFRACTION (1.12 Å) |
Structure validation
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