4NKC

Human Aldose Reductase complexed with Schl7764 at 1.12 A

Summary for 4NKC

• Entry DOI: 10.2210/pdb4nkc/pdb
• Related: 2IKG 2IKH 3DN5
• Descriptor: Aldose reductase, (2Z)-3-(3'-nitrobiphenyl-3-yl)prop-2-enoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: tim barrel, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 36779.80

Authors

Rechlin, C.,Heine, A.,Klebe, G. (deposition date: 2013-11-12, release date: 2015-03-04, Last modification date: 2023-09-20)

• Primary citation: Rechlin, C.,Heine, A.,Ortmann, R.,Schlitzer, M.,Klebe, G.; Keys to open the specificity pocket: Biaryl Inhibitors of the human aldose reductase; To be Published,

Experimental method

X-RAY DIFFRACTION (1.12 Å)