4NG6

The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

4NG6 の概要

• エントリーDOI: 10.2210/pdb4ng6/pdb
• 関連するPDBエントリー: 1YQ7 4KFA 4KQ5 4KQS
• 分子名称: Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: alpha-helical prenyltransferase, isoprene biosynthesis, lipid synthesis, steroid biosynthesis, transferase, isoprenoid pathway, cholesterol synthesis, bisphosphonates
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P14324
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43731.08

構造登録者

Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Pilka, E.,Kwaasi, A.A.,Kavanagh, K.L.,Evdokimov, A.,Walter, R.L.,Ebetino, F.H.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E. (登録日: 2013-11-01, 公開日: 2014-11-19, 最終更新日: 2023-09-20)

• 主引用文献: Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Pilka, E.,Kwaasi, A.A.,Kavanagh, K.L.,Evdokimov, A.,Walter, R.L.,Ebetino, F.H.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E.; The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates; TO BE PUBLISHED,

実験手法

X-RAY DIFFRACTION (2.35 Å)