4KFA

Crystal structure of human farnesyl pyrophosphate synthase (t201a mutant) complexed with mg and zoledronate

Summary for 4KFA

• Entry DOI: 10.2210/pdb4kfa/pdb
• Related: 1ZW5 2VF6
• Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, ZOLEDRONIC ACID, ... (5 entities in total)
• Functional Keywords: isoprene biosynthesis, lipid synthesis, steroid biosynthesis, transferase, isopentyl pyrophosphate and dimethylallyl pyrophosphate, isoprenoid pathway, cholesterol synthesis, bisphosphonates, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 43522.03

Authors

Barnett, B.L.,Tsoumpra, M.K.,Muniz, J.R.C.,Walter, R.L. (deposition date: 2013-04-26, release date: 2014-04-30, Last modification date: 2023-09-20)

• Primary citation: Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Pilka, E.,Kwaasi, A.,Kavanagh, K.L.,Evdokimov, A.G.,Walter, R.L.,Ebetino, F.H.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E.; Crystal structure of human farnesyl pyrophosphate synthase (t201a mutant) complexed with mg and zoledronate; To be Published,

Experimental method

X-RAY DIFFRACTION (1.98 Å)