4KFA

Crystal structure of human farnesyl pyrophosphate synthase (t201a mutant) complexed with mg and zoledronate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Farnesyl pyrophosphate synthase	polymer	375	43115.0	1	UniProt (P14324) Pfam (PF00348) In PDB	Homo sapiens (human)	FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase
2	A	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
3	A	ZOLEDRONIC ACID	non-polymer		272.1	1	Chemie (ZOL)
4	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5		water	water		18.0	214	Chemie (HOH)

Sequence modifications

A: 1 - 353 (UniProt: P14324)

PDB	External Database	Details
Met -21	-	expression tag
Gly -20	-	expression tag
Ser -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Arg -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag
Ala 201	Thr 267	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43115.0
Non-Polymers*	Number of molecules	5
	Total formula weight	407.1
All*	Total formula weight	43522.0

*Water molecules are not included.