4NEF

X-ray structure of human Aquaporin 2

Summary for 4NEF

Entry DOI	10.2210/pdb4nef/pdb
Descriptor	Aquaporin-2, CADMIUM ION, ZINC ION, ... (4 entities in total)
Functional Keywords	water channel, cadmium binding, membrane protein
Biological source	Homo sapiens (human)
Cellular location	Apical cell membrane ; Multi-pass membrane protein : P41181
Total number of polymer chains	4
Total formula weight	101235.57
Authors	Frick, A.,Eriksson, U.,Mattia, F.D.,Oberg, F.,Hedfalk, K.,Neutze, R.,Grip, W.D.,Deen, P.M.T.,Tornroth-horsefield, S. (deposition date: 2013-10-29, release date: 2014-04-16, Last modification date: 2014-12-10)
Primary citation	Frick, A.,Eriksson, U.K.,de Mattia, F.,Oberg, F.,Hedfalk, K.,Neutze, R.,de Grip, W.J.,Deen, P.M.,Tornroth-Horsefield, S. X-ray structure of human aquaporin 2 and its implications for nephrogenic diabetes insipidus and trafficking Proc.Natl.Acad.Sci.USA, 111:6305-6310, 2014 Cited by PubMed: 24733887 DOI: 10.1073/pnas.1321406111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation