4NCT

Human DYRK1A in complex with PKC412

Summary for 4NCT

Entry DOI	10.2210/pdb4nct/pdb
Descriptor	Dual specificity tyrosine-phosphorylation-regulated kinase 1A, PKC412, ... (4 entities in total)
Functional Keywords	protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Nucleus : Q13627 Q13627
Total number of polymer chains	4
Total formula weight	172978.49
Authors	Alexeeva, M.O.,Rothweiler, U. (deposition date: 2013-10-25, release date: 2015-04-01, Last modification date: 2017-11-15)
Primary citation	Alexeeva, M.,Aberg, E.,Engh, R.A.,Rothweiler, U. The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine. Acta Crystallogr.,Sect.D, 71:1207-1215, 2015 Cited by PubMed: 25945585 DOI: 10.1107/S1399004715005106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.597 Å)

Structure validation