4NCT
Human DYRK1A in complex with PKC412
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D (A, B, D) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 368 | 42654.0 | 3 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (human) | Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB |
| 2 | C (C) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 368 | 42734.0 | 1 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (human) | Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB |
| 3 | E, F, G, H (A, B, C, D) | PKC412 | non-polymer | 570.6 | 4 | Chemie (2K2) | |||
| 4 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 211 | Chemie (HOH) |
Sequence modifications
A, B, D: 126 - 490 (UniProt: Q13627)
C: 126 - 490 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| Gly 123 | - | expression tag |
| Ala 124 | - | expression tag |
| Ser 125 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 123 | - | expression tag |
| Ala 124 | - | expression tag |
| Ser 125 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 170695.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2282.5 | |
| All* | Total formula weight | 172978.5 |
