4NCT
Human DYRK1A in complex with PKC412
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D (A, B, D) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 368 | 42654.0 | 3 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (human) | Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB |
| 2 | C (C) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 368 | 42734.0 | 1 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (human) | Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB |
| 3 | E, F, G, H (A, B, C, D) | PKC412 | non-polymer | 570.6 | 4 | Chemie (2K2) PubChem (16760627) PubChem (24202429) PubChem (44120162) PubChem (51004351) PubChem (59783146) PubChem (71018774) PubChem (71719722) PubChem (91613430) PubChem (92402815) PubChem (95065542) PubChem (124915819) PubChem (9829523) PubChem (129886950) PubChem (146156652) PubChem (59476509) PubChem (59476520) PubChem (67599378) PubChem (101631538) PubChem (124524326) PubChem (124585888) PubChem (134490683) PubChem (138756138) | |||
| 4 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 211 | Chemie (HOH) |
Sequence modifications
A, B, D: 126 - 490 (UniProt: Q13627)
C: 126 - 490 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| Gly 123 | - | expression tag |
| Ala 124 | - | expression tag |
| Ser 125 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 123 | - | expression tag |
| Ala 124 | - | expression tag |
| Ser 125 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 170695.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2282.5 | |
| All* | Total formula weight | 172978.5 |
