4NCT

Human DYRK1A in complex with PKC412

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, D	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	polymer	368	42654.0	3	UniProt (Q13627) Pfam (PF00069) In PDB	Homo sapiens (human)	Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB
2	C	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	polymer	368	42734.0	1	UniProt (Q13627) Pfam (PF00069) In PDB	Homo sapiens (human)	Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB
3	A, B, C, D	PKC412	non-polymer		570.6	4	Chemie (2K2)
4		water	water		18.0	211	Chemie (HOH)

Sequence modifications

A, B, D: 126 - 490 (UniProt: Q13627)

PDB	External Database	Details
Gly 123	-	EXPRESSION TAG
Ala 124	-	EXPRESSION TAG
Ser 125	-	EXPRESSION TAG

C: 126 - 490 (UniProt: Q13627)

PDB	External Database	Details
Gly 123	-	EXPRESSION TAG
Ala 124	-	EXPRESSION TAG
Ser 125	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	170695.9
Non-Polymers*	Number of molecules	4
	Total formula weight	2282.5
All*	Total formula weight	172978.5

*Water molecules are not included.