4N49

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Protein in complex with m7GpppG and SAM

Summary for 4N49

Entry DOI	10.2210/pdb4n49/pdb
Related	4N48 4N4A
Descriptor	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, S-ADENOSYLMETHIONINE, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywords	methyltransferase, mrna cap methylation, mrna, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus : Q8N1G2
Total number of polymer chains	1
Total formula weight	49896.40
Authors	Smietanski, M.,Werener, M.,Purta, E.,Kaminska, K.H.,Stepinski, J.,Darzynkiewicz, E.,Nowotny, M.,Bujnicki, J.M. (deposition date: 2013-10-08, release date: 2014-01-22, Last modification date: 2023-09-20)
Primary citation	Smietanski, M.,Werner, M.,Purta, E.,Kaminska, K.H.,Stepinski, J.,Darzynkiewicz, E.,Nowotny, M.,Bujnicki, J.M. Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation. Nat Commun, 5:3004-3004, 2014 Cited by PubMed: 24402442 DOI: 10.1038/ncomms4004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation