4MVY
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-(3-hydroxyphenyl)urea (Chem 1387)
Replaces: 3U1ESummary for 4MVY
Entry DOI | 10.2210/pdb4mvy/pdb |
Related | 4EG1 4EG3 4EG5 4MVW 4MVX 4MW0 4MW1 4MW2 4MW4 4MW5 4MW6 4MW7 4MW9 4MWB 4MWC 4MWD 4MWE |
Descriptor | Methionyl-tRNA synthetase, GLYCEROL, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | aminoacyl-trna synthetase, aars, metrs, parasite, protein-inhibitor complex, rossmann fold, translation, nucleotide binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Trypanosoma brucei |
Total number of polymer chains | 2 |
Total formula weight | 124358.03 |
Authors | Koh, C.Y.,Kim, J.E.,Wetzel, A.B.,de van der Schueren, W.J.,Shibata, S.,Liu, J.,Zhang, Z.,Fan, E.,Verlinde, C.L.M.J.,Hol, W.G.J. (deposition date: 2013-09-24, release date: 2014-04-30, Last modification date: 2023-09-20) |
Primary citation | Koh, C.Y.,Kim, J.E.,Wetzel, A.B.,de van der Schueren, W.J.,Shibata, S.,Ranade, R.M.,Liu, J.,Zhang, Z.,Gillespie, J.R.,Buckner, F.S.,Verlinde, C.L.,Fan, E.,Hol, W.G. Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8:e2775-e2775, 2014 Cited by PubMed: 24743796DOI: 10.1371/journal.pntd.0002775 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.314 Å) |
Structure validation
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