4MVY
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-(3-hydroxyphenyl)urea (Chem 1387)
Replaces: 3U1EFunctional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
A | 0004825 | molecular_function | methionine-tRNA ligase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
B | 0004825 | molecular_function | methionine-tRNA ligase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 801 |
Chain | Residue |
A | TRP345 |
A | GLU349 |
A | TYR405 |
A | PRO464 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 802 |
Chain | Residue |
A | PRO462 |
A | HIS289 |
A | LYS338 |
A | ASN458 |
A | TRP459 |
A | ALA460 |
site_id | AC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE GOL A 803 |
Chain | Residue |
A | ARG719 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS A 804 |
Chain | Residue |
A | LYS521 |
A | DMS805 |
A | HOH1025 |
A | HOH1106 |
A | HOH1178 |
site_id | AC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS A 805 |
Chain | Residue |
A | DMS804 |
site_id | AC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL A 806 |
Chain | Residue |
A | ARG583 |
A | ARG601 |
site_id | AC7 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE MET A 807 |
Chain | Residue |
A | ILE248 |
A | TYR250 |
A | ASP287 |
A | TRP474 |
A | ALA477 |
A | TYR481 |
A | ILE519 |
A | HIS523 |
A | HOH978 |
A | HOH979 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 801 |
Chain | Residue |
B | GLU343 |
B | LYS347 |
B | LEU482 |
B | ARG486 |
B | HOH981 |
site_id | AC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL B 802 |
Chain | Residue |
B | ARG583 |
B | ARG601 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 803 |
Chain | Residue |
B | HIS289 |
B | THR333 |
B | LYS338 |
B | ASN458 |
B | TRP459 |
B | ALA460 |
B | CAS470 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 804 |
Chain | Residue |
B | ASN612 |
B | ARG616 |
B | HOH935 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS B 805 |
Chain | Residue |
B | GLU320 |
B | TYR324 |
B | SER325 |
B | ILE326 |
B | HOH1106 |
site_id | BC4 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE 387 B 806 |
Chain | Residue |
B | ILE248 |
B | TYR250 |
B | ASP287 |
B | HIS289 |
B | GLY290 |
B | LEU456 |
B | VAL471 |
B | TYR472 |
B | VAL473 |
B | TRP474 |
B | ASP476 |
B | ALA477 |
B | TYR481 |
B | ILE519 |
B | HIS523 |
B | HOH995 |
B | HOH1080 |
B | HOH1128 |
B | HOH1167 |