4MPX

Human beta-tryptase co-crystal structure with [(1,1,3,3-tetramethyldisiloxane-1,3-diyl)di-1-benzothiene-4,2-diyl]bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)

Summary for 4MPX

• Entry DOI: 10.2210/pdb4mpx/pdb
• Related: 4MPU 4MPV 4MPW 4MQA
• Descriptor: Tryptase alpha/beta-1, SULFATE ION, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: coferon, alpha-hydroxyketone, small molecule inhibitor, drug discovery, self-assembly, crystal catalysis, silanol, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: Q15661
• Total number of polymer chains: 2
• Total formula weight: 56860.90

Authors

White, A.,Stein, A.J.,Suto, R. (deposition date: 2013-09-13, release date: 2015-03-18)

• Primary citation: Giardina, S.F.,Pingle, M.,Foreman, K.W.,Werner, D.S.,Bergstrom, D.E.,Barany, F.,Arnold, L.D.; Target-directed self-assembly of homodimeric drugs; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)