4MPX
Human beta-tryptase co-crystal structure with [(1,1,3,3-tetramethyldisiloxane-1,3-diyl)di-1-benzothiene-4,2-diyl]bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Tryptase alpha/beta-1 | polymer | 245 | 27491.4 | 2 | UniProt (Q15661) Pfam (PF00089) In PDB | Homo sapiens (human) | Tryptase-1, Tryptase I, Tryptase alpha-1 |
| 2 | A, B | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | A, B | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 5 | B | [(1,1,3,3-tetramethyldisiloxane-1,3-diyl)di-1-benzothiene-4,2-diyl]bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone) | non-polymer | 831.2 | 1 | Chemie (2AV) | |||
| 6 | B | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 7 | water | water | 18.0 | 309 | Chemie (HOH) |
Sequence modifications
A, B: 31 - 275 (UniProt: Q15661)
| PDB | External Database | Details |
|---|---|---|
| Lys 132 | Asn 132 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54982.9 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1878.1 | |
| All* | Total formula weight | 56860.9 |
