4MPX

Human beta-tryptase co-crystal structure with [(1,1,3,3-tetramethyldisiloxane-1,3-diyl)di-1-benzothiene-4,2-diyl]bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0006952	biological_process	defense response
A	0008236	molecular_function	serine-type peptidase activity
A	0022617	biological_process	extracellular matrix disassembly
A	0042802	molecular_function	identical protein binding
A	0062023	cellular_component	collagen-containing extracellular matrix
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006508	biological_process	proteolysis
B	0006952	biological_process	defense response
B	0008236	molecular_function	serine-type peptidase activity
B	0022617	biological_process	extracellular matrix disassembly
B	0042802	molecular_function	identical protein binding
B	0062023	cellular_component	collagen-containing extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 301

Chain	Residue
A	HIS138
A	TRP236
A	HOH460
A	HOH530

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	HIS74
A	GLN221
A	GLY222
A	SER224

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 303

Chain	Residue
A	LYS179
A	ARG217
A	GLN35

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE A 304

Chain	Residue
A	VAL50
A	PHE58
A	LYS81
A	ASP82
A	ALA85
A	HOH544

---

site_id	AC5
Number of Residues	25
Details	BINDING SITE FOR RESIDUE 2AV B 301

Chain	Residue
A	THR115
A	GLN117
A	ASP218
A	SER219
A	CYS220
A	GLN221
A	SER224
A	TRP244
A	GLY245
A	GLU246
A	GLY247
A	GLY255
A	HOH408
B	GLN117
B	ASP218
B	SER219
B	CYS220
B	SER224
B	VAL242
B	TRP244
B	GLY245
B	GLU246
B	GLY247
B	CYS248
B	HOH413

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	HIS74
B	GLN221
B	GLY222
B	SER224

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 303

Chain	Residue
A	HIS136
B	GLU128
B	HIS186
B	ARG203
B	MES307

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 304

Chain	Residue
B	ASN214
B	THR215
B	ARG216

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 305

Chain	Residue
B	ASN185

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE B 306

Chain	Residue
B	VAL50
B	PHE58
B	LYS81
B	ASP82
B	ALA85
B	HOH504

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MES B 307

Chain	Residue
A	LYS132
A	HIS136
A	HOH468
B	ARG203
B	ARG206
B	ASP207
B	SO4303

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU70-CYS75

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
A	ASP218-VAL229

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
A	HIS74
A	ASP121
A	SER224
B	HIS74
B	ASP121
B	SER224

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	LYS132
B	LYS132

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN233
B	ASN233

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