4MNV

Crystal structure of bicyclic peptide UK729 bound as an acyl-enzyme intermediate to urokinase-type plasminogen activator (uPA)

Summary for 4MNV

Entry DOI	10.2210/pdb4mnv/pdb
Related	2NWN 3QN7 4GLY 4JK5 4JK6 4MNW 4MNX 4MNY
Descriptor	Urokinase-type plasminogen activator chain B, acyl-enzyme intermediate of bicyclic peptide UK729, SULFATE ION, ... (8 entities in total)
Functional Keywords	acyl-enzyme intermediate, inhibitor, protease, 1, 3, 5-tris(bromomethyl)benzene (tbmb) cyclization, extracellular, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P00749
Total number of polymer chains	3
Total formula weight	29725.31
Authors	Chen, S.,Pojer, F.,Heinis, C. (deposition date: 2013-09-11, release date: 2014-02-05, Last modification date: 2017-11-15)
Primary citation	Chen, S.,Bertoldo, D.,Angelini, A.,Pojer, F.,Heinis, C. Peptide ligands stabilized by small molecules. Angew.Chem.Int.Ed.Engl., 53:1602-1606, 2014 Cited by PubMed: 24453110 DOI: 10.1002/anie.201309459 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation