4MK0

Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative

4MK0 の概要

• エントリーDOI: 10.2210/pdb4mk0/pdb
• 関連するPDBエントリー: 1OMW 3V5W 4L9I
• 分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: inhibitor complex, protein kinase, hydrolase, atp binding, phosphorylation, peripheral membrane protein, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm : P25098; Cell membrane ; Lipid-anchor ; Cytoplasmic side : P63212
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 118781.37

構造登録者

Homan, K.T.,Tesmer, J.J.G. (登録日: 2013-09-04, 公開日: 2014-01-22, 最終更新日: 2024-02-28)

• 主引用文献: Homan, K.T.,Wu, E.,Wilson, M.W.,Singh, P.,Larsen, S.D.,Tesmer, J.J.; Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.; Mol.Pharmacol., 85:237-248, 2014; PubMed: 24220010; DOI: 10.1124/mol.113.089631

実験手法

X-RAY DIFFRACTION (2.4 Å)