4MBK
Crystal structure of K234R inhibitor-resistant variant of SHV beta-lactamase in complex with SA2-13
Summary for 4MBK
Entry DOI | 10.2210/pdb4mbk/pdb |
Related | 2H5S 4MBF 4MBH |
Descriptor | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, ... (4 entities in total) |
Functional Keywords | class a beta-lactamase, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 30317.59 |
Authors | Rodkey, E.A.,van den Akker, F. (deposition date: 2013-08-19, release date: 2014-07-30, Last modification date: 2017-11-15) |
Primary citation | Rodkey, E.A.,Winkler, M.L.,Bethel, C.R.,Pagadala, S.R.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F. Penam sulfones and beta-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition. Plos One, 9:e85892-e85892, 2014 Cited by PubMed: 24454944DOI: 10.1371/journal.pone.0085892 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.46 Å) |
Structure validation
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