4LTC
Crystal structure of yeast 20S proteasome in complex with enone carmaphycin analogue 6
Summary for 4LTC
Entry DOI | 10.2210/pdb4ltc/pdb |
Related | 4HNP 4HRC 4HRD |
Related PRD ID | PRD_001161 |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (16 entities in total) |
Functional Keywords | proteasome, inhibitor, carmaphycin, epoxyketone, vinylketone, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 729331.09 |
Authors | |
Primary citation | Trivella, D.B.,Pereira, A.R.,Stein, M.L.,Kasai, Y.,Byrum, T.,Valeriote, F.A.,Tantillo, D.J.,Groll, M.,Gerwick, W.H.,Moore, B.S. Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chem.Biol., 21:782-791, 2014 Cited by PubMed: 24930969DOI: 10.1016/j.chembiol.2014.04.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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