Crystal structure of yeast 20S proteasome in complex with enone carmaphycin analogue 6

Summary for 4LTC

Related4HRD 4HRC 4HNP
Related PRD IDPRD_001161
DescriptorProteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... (16 entities in total)
Functional Keywordsproteasome, inhibitor, carmaphycin, epoxyketone, vinylketone, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight729331.09
Stein, M.,Trivella, D.B.B.,Groll, M. (deposition date: 2013-07-23, release date: 2014-07-02)
Primary citation
Trivella, D.B.,Pereira, A.R.,Stein, M.L.,Kasai, Y.,Byrum, T.,Valeriote, F.A.,Tantillo, D.J.,Groll, M.,Gerwick, W.H.,Moore, B.S.
Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor.
Chem.Biol., 21:782-791, 2014
PubMed: 24930969 (PDB entries with the same primary citation)
DOI: 10.1016/j.chembiol.2014.04.010
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2332 0.3% 3.9% 3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-23