4LQC
The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP show structural differences in microbial TIR mimicry.
Summary for 4LQC
Entry DOI | 10.2210/pdb4lqc/pdb |
Related | 4LQD |
Descriptor | TcpB (2 entities in total) |
Functional Keywords | tir, tirap molecular mimic, myd88 binding, innate immunity, flavodoxin fold, bacterial tir like domain, myd88, proteolytic fragment from alpha 2 chymotrypsin, cytoplasmic, immune system |
Biological source | Brucella melitensis |
Total number of polymer chains | 2 |
Total formula weight | 33760.30 |
Authors | Snyder, G.A.,Smith, P.,Fresquez, T.,Cirl, C.,Jiang, J.,Snyder, N.,Luchetti, T.,Miethke, T.,Xiao, T.S. (deposition date: 2013-07-17, release date: 2013-12-04, Last modification date: 2024-02-28) |
Primary citation | Snyder, G.A.,Deredge, D.,Waldhuber, A.,Fresquez, T.,Wilkins, D.Z.,Smith, P.T.,Durr, S.,Cirl, C.,Jiang, J.,Jennings, W.,Luchetti, T.,Snyder, N.,Sundberg, E.J.,Wintrode, P.,Miethke, T.,Xiao, T.S. Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. J.Biol.Chem., 289:669-679, 2014 Cited by PubMed: 24275656DOI: 10.1074/jbc.M113.523407 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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