4LQ3

Crystal structure of human norovirus RNA-dependent RNA-polymerase bound to the inhibitor PPNDS

Summary for 4LQ3

• Entry DOI: 10.2210/pdb4lq3/pdb
• Related: 4LQ9
• Descriptor: RNA-dependent RNA-polymerase, 5'-R(P*GP*G)-3', 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid, ... (5 entities in total)
• Functional Keywords: rna-dependent-rna-polymerase, rdrp-inhibotir complex, viral protein-replication inhibitor-rna complex, viral protein/replication inhibitor/rna
• Biological source: Norovirus
• Total number of polymer chains: 2
• Total formula weight: 61753.26

Authors

Milani, M.,Tarantino, D.,Mastrangelo, E.,Croci, R. (deposition date: 2013-07-17, release date: 2014-02-12, Last modification date: 2024-02-28)

• Primary citation: Tarantino, D.,Pezzullo, M.,Mastrangelo, E.,Croci, R.,Rohayem, J.,Robel, I.,Bolognesi, M.,Milani, M.; Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase.; Antiviral Res., 102:23-28, 2014; PubMed: 24316032; DOI: 10.1016/j.antiviral.2013.11.016

Experimental method

X-RAY DIFFRACTION (2.6 Å)