4LQ3
Crystal structure of human norovirus RNA-dependent RNA-polymerase bound to the inhibitor PPNDS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001172 | biological_process | RNA-templated transcription |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0039694 | biological_process | viral RNA genome replication |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 20V A 601 |
| Chain | Residue |
| A | LYS146 |
| A | GLU323 |
| A | VAL324 |
| A | THR325 |
| A | ASN326 |
| A | ASP354 |
| A | LYS357 |
| A | 20V602 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 20V A 602 |
| Chain | Residue |
| A | HIS123 |
| A | ASP142 |
| A | GLN143 |
| A | LYS357 |
| A | 20V601 |
| A | PRO122 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 20V A 603 |
| Chain | Residue |
| A | LYS166 |
| A | ASP167 |
| A | GLU168 |
| A | ARG392 |
| A | LEU406 |
| A | SER410 |
| A | ILE411 |
| A | ARG413 |
| A | GLN414 |
| A | ARG419 |
| A | GLN439 |
| A | LEU443 |
| A | ASP507 |
| A | GLU510 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 20V A 604 |
| Chain | Residue |
| A | ARG252 |
| A | ILE463 |
| A | ALA464 |
| A | LYS467 |
| A | HOH789 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 605 |
| Chain | Residue |
| A | ASP240 |
| A | ASP344 |
| A | GLU345 |
| A | THR389 |






