4LNG

Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib

4LNG の概要

• エントリーDOI: 10.2210/pdb4lng/pdb
• 関連するPDBエントリー: 4L9P 4LNB
• 分子名称: CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, 1,2-ETHANEDIOL, ... (8 entities in total)
• 機能のキーワード: farnesyltransferase, prenylation, isoprenoid and caax-containing protein and peptide substrates, farnesylation, transferase
• 由来する生物種: Aspergillus fumigatus; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100313.83

構造登録者

Mabanglo, M.F.,Hast, M.A.,Beese, L.S. (登録日: 2013-07-11, 公開日: 2014-01-01, 最終更新日: 2024-02-28)

• 主引用文献: Mabanglo, M.F.,Hast, M.A.,Lubock, N.B.,Hellinga, H.W.,Beese, L.S.; Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.; Protein Sci., 23:289-301, 2014; PubMed: 24347326; DOI: 10.1002/pro.2411

実験手法

X-RAY DIFFRACTION (1.905 Å)