4LNG
Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | CaaX farnesyltransferase alpha subunit Ram2 | polymer | 367 | 42391.5 | 1 | UniProt (Q4WP27) Pfam (PF01239) In PDB | Aspergillus fumigatus | |
| 2 | B | CaaX farnesyltransferase beta subunit Ram1 | polymer | 519 | 56635.8 | 1 | UniProt (Q4WPS9) Pfam (PF00432) In PDB | Aspergillus fumigatus | |
| 3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 4 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | B | 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE | non-polymer | 489.4 | 1 | Chemie (JAN) | |||
| 6 | B | FARNESYL DIPHOSPHATE | non-polymer | 382.3 | 1 | Chemie (FPP) | |||
| 7 | B | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 8 | water | water | 18.0 | 595 | Chemie (HOH) |
Sequence modifications
A: 1 - 353 (UniProt: Q4WP27)
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| Gly -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Ser -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Ser 146 | Asn 146 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 99027.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1286.6 | |
| All* | Total formula weight | 100313.8 |
