4LNG
Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0004660 | molecular_function | protein farnesyltransferase activity |
| A | 0004662 | molecular_function | CAAX-protein geranylgeranyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005953 | cellular_component | CAAX-protein geranylgeranyltransferase complex |
| A | 0005965 | cellular_component | protein farnesyltransferase complex |
| A | 0007323 | biological_process | peptide pheromone maturation |
| A | 0008318 | molecular_function | protein prenyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018342 | biological_process | protein prenylation |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0004660 | molecular_function | protein farnesyltransferase activity |
| B | 0005965 | cellular_component | protein farnesyltransferase complex |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008318 | molecular_function | protein prenyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0018343 | biological_process | protein farnesylation |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0097354 | biological_process | prenylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 401 |
| Chain | Residue |
| A | THR43 |
| A | ARG47 |
| A | MET50 |
| A | HIS73 |
| A | EDO402 |
| B | HIS194 |
| B | GLY195 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 402 |
| Chain | Residue |
| A | ARG47 |
| A | EDO401 |
| A | HOH577 |
| A | HOH629 |
| B | ASP148 |
| A | TYR35 |
| A | THR43 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 601 |
| Chain | Residue |
| B | ASP365 |
| B | CYS367 |
| B | HIS433 |
| B | JAN602 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE JAN B 602 |
| Chain | Residue |
| B | SER150 |
| B | TRP157 |
| B | ASP365 |
| B | CYS367 |
| B | TYR368 |
| B | ASP430 |
| B | TYR432 |
| B | HIS433 |
| B | ZN601 |
| B | FPP603 |
| B | EDO604 |
| B | EDO606 |
| B | HOH843 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE FPP B 603 |
| Chain | Residue |
| B | ARG252 |
| B | HIS311 |
| B | ALA313 |
| B | TYR314 |
| B | ARG359 |
| B | LYS362 |
| B | TYR368 |
| B | TRP371 |
| B | TYR432 |
| B | JAN602 |
| B | HOH750 |
| B | HOH829 |
| B | HOH892 |
| B | HOH940 |
| B | HOH1011 |
| B | HOH1012 |
| B | HOH1027 |
| B | HOH1039 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 604 |
| Chain | Residue |
| B | TYR132 |
| B | MET154 |
| B | ASP430 |
| B | SER431 |
| B | TYR432 |
| B | JAN602 |
| B | HOH814 |
| B | HOH833 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 605 |
| Chain | Residue |
| B | ALA149 |
| B | SER150 |
| B | TRP153 |
| B | HIS199 |
| B | SER202 |
| B | K607 |
| B | HOH840 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 606 |
| Chain | Residue |
| A | TYR109 |
| B | ASP250 |
| B | ARG252 |
| B | TYR314 |
| B | JAN602 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K B 607 |
| Chain | Residue |
| B | TRP153 |
| B | ALA201 |
| B | ARG252 |
| B | EDO605 |
